Activated by the antibiotic rifampicin and various plant metabolites, including hyperforin, guggulipid, colupulone, and isoflavones. Reaction to distinct ligands is species-precise. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a reaction aspect from the promoters with the CYP3A4 and ABCB1/MDR1 genesSyme